List of largest selling pharmaceutical products

The following is a list of the top 100 pharmaceutical products ranked by sales in U.S. dollars for Q1 2014.

Rank	Brand Name(s)	Generic Name	Sales Q1 2014Sales ($000)	Change from Q4 2013	Company(ies)	Disease/Medical Use	First Approval Date	Patent Expiration Date[1][2]
1	Abilify	Aripiprazole	1,602,329	2.23%	Bristol-Myers Squibb, Otsuka Pharmaceutical	Psychosis; depression	Nov-2002	Oct-2014
2	Humira	Adalimumab	1,561,861	3.86%	Abbott Laboratories	Crohn's disease; Rheumatoid arthritis	Dec-2002	Dec-2016
3	Nexium	Esomeprazole	1,536,435	0.74%	AstraZeneca	Gastrointestinal disorders	Mar-2000	May-2014
4	Crestor	Rosuvastatin	1,333,502	4.53%	AstraZeneca,Shionogi	Cholesterol	Nov-2002	Jul-2016
5	Enbrel	Etanercept	1,189,844	1.46%	Amgen	Rheumatoid arthritis	Nov-1998	Oct-2012
6	Advair Diskus, Seretide	Fluticasone/salmeterol	1,147,330	2.65%	GlaxoSmithKline	Asthma	Aug-2000	Mar-2012
8	Remicade	Infliximab	994,020	-2.71%	Centocor Ortho Biotech, Inc.,Mitsubishi Tanabe Pharma	Crohn's disease; rheumatoid arthritis	Aug-1998	n/a
9	Lantus Solostar	Insulin glargine	939,691	9.39%	Sanofi-Aventis	Diabetes mellitus type 1 and 2	Apr-2000	Dec-2011
10	Neulasta	Filgrastim	854,508	-4.90%	Amgen	Neutropenia	Jan-2002	Mon-20XX
11	Copaxone	Glatiramer	851,351	-4.69%	Sanofi-Aventis,Teva Pharmaceutical Industries	Multiple sclerosis	Dec-1996	Nov-2014
12	Rituxan, MabThera	Rituximab	746,766	-0.16%	Biogen Idec,Chugai Pharmaceutical,Genentech/Roche	Non-Hodgkin’s lymphoma; rheumatoid arthritis	Nov-1997	Mon-20XX
13	Spiriva	Tiotropium bromide	726,057	3.39%	Boehringer Ingelheim	Chronic obstructive pulmonary disease	Apr-2002	Jul-2018
14	Januvia	Sitagliptin	700,941	3.63%	Merck & Co., Inc.	Diabetes mellitus type 2	Dec-1996	Nov-2017
15	Lantus	Insulin glargine	685,461	5.84%	Sanofi-Aventis	Diabetes mellitus type 1 and 2	Apr-2000	Dec-2011
16	Atripla	Emtricitabine/tenofovir/efavirenz	679,418	0.36%	Gilead Sciences, Inc.	HIV infection	Dec-1996	Mar-2015
17	Cymbalta	Duloxetine	664,186	-23.06%	Eli Lilly and Company	Depression; anxiety disorders	Aug-2004	Dec-2013
18	Avastin	Bevacizumab	650,208	-1.25%	Genentech/Roche	Cancer	Feb-2004	Mon-20XX
19	Lyrica	Pregabalin	624,774	2.82%	Pfizer	Neuropathic pain	Jul-2004	Jul-2019
20	OxyContin	Oxycodone	585,482	-2.91%	Purdue Pharma	Pain	Dec-1996	Mon-20XX
21	Celebrex	Celecoxib	580,332	5.23%	Pfizer	Osteoarthritis; rheumatoid arthritis	Dec-1998	May-2014
22	Epogen	Epoetin alfa	503,493	−2.08%	Amgen	Anemia	Jun-1989	Mon-20XX
23	Truvada	Tenofovir/emtricitabine	542,846	0.03%	Gilead Sciences	HIV infection	Aug-2004	Mon-20XX
24	Diovan	Valsartan	533,924	2.80%	Novartis	Hypertension	Dec-1996	Sep-2012
25	Levemir	Insulin detemir	424,186	9.34%	Novo Nordisk	Diabetes mellitus type 1 and 2	Dec-1990	Mon-20XX
26	Gleevec, Glivec	Imatinib	498,149	7.22%	Novartis	Leukemia	May-2001	Jan-2015
27	Herceptin	Trastuzumab	473,632	1.53%	Chugai Pharmaceutical,Genentech/Roche	Breast cancer	Sep-1998	Mon-20XX
28	Vyvanse	Lisdexamfetamine	447,188	9.39%	Shire	Attention deficit hyperactivity disorder	Dec-1990	Mon-20XX
29	Lucentis	Ranibizumab	460,621	-0.84%	Genentech	Macular degeneration	Dec-1990	Mon-20XX
30	Zetia	Ezetimibe	444,731	4.04%	Merck & Co.,Schering-Plough	Cholesterol	Oct-2002	Oct-2017
31	Tecfidera	Ipratropium bromide/salbutamol	391,404	20.28%	Boehringer Ingelheim	Chronic obstructive pulmonary disease	Oct-1996	Mon-20XX
32	Symbicort	Budesonide/formoterol	407,646	9.63%	AstraZeneca	Asthma	Aug-2000	Mon-20XX
33	Namenda	Memantine	434,766	-6.00%	Forest Laboratories	Alzheimer's disease	Oct-2003	Apr-2014
34	NovoLog FlexPen	Insulin aspart	364,870	7.84%	Novo Nordisk	Diabetes mellitus type 1 and 2	Oct-1996	Mon-20XX
35	Xarelto	Rivaroxaban	321,462	18.72%	Bayer	Oral anticoagulant	Dec-1996	Sep-2012
36	NovoLog	Insulin aspart	344,235	3.86%	Novo Nordisk	Diabetes mellitus type 1 and 2	Oct-1996	Mon-20XX
37	Humalog	Insulin lispro	304,866	6.15%	Eli Lilly and Company	Diabetes mellitus type 1 and 2	Apr-1996	Mon-20XX
38	Suboxone	Buprenorphine	321,892	-2.11%	Reckitt Benckiser Pharmaceuticals Inc.	Pain; opioid addiction	Aug-2000	Mon-20XX
40	Viagra	Sildenafil	300,463	3.26%	Pfizer	Erectile dysfunction	Mar-1998	Mar-2012
41	Seroquel XR	Quetiapine	291,494	2.22%	AstraZeneca	Psychosis; depression	Sep-1997	Mar-2012
33	ONE TOUCH ULTRA	Telaprevir	370,899	0.00%	Johnson & Johnson	Hepatitis C[citation needed]	Dec-1990	Mon-20XX
35	AndroGel	Testosterone gel	351,737	5.47%	Abbott Laboratories,Schering-Plough	Low testosterone levels	Oct-2002	Oct-2016
37	Enoxaparin	Enoxaparin	341,184	6.55%	Generic	Deep-vein thrombosis	Mar-1993	Aug-2012
38	Methylphenidate	Methylphenidate	327,346	2.26%	Generic	Attention deficit hyperactivity disorder	Aug-2000	Mon-20XX
41	ProAir HFA	Salbutamol	306,461	10.87%	Teva Pharmaceuticals	Asthma; chronic obstructive pulmonary disease	Oct-1996	Mon-20XX
43	Alimta	Pemetrexed	302,728	6.00%	Eli Lilly and Company	Cancer	Feb-2004	Mon-20XX
44	Victoza	Liraglutide	301,414	9.59%	Novo Nordisk	Diabetes mellitus type 2	May-1909	Mon-20XX
47	Synagis	Palivizumab	289,704	0.00%	MedImmune	RSV infection	Feb-1998	Aug-2012
48	Avonex	Interferon beta 1a	281,554	-1.43%	Biogen Idec	Multiple sclerosis	May-1996	Mon-20XX
49	Renvela	Sevelamer	280,917	21.44%	Genzyme Corporation,Forest Laboratories	Hyperphosphatemia	Apr-2002	Apr-2016
50	Rebif	Interferon beta 1a	280,548	-6.27%	Serono	Multiple sclerosis	Feb-1998	Mon-20XX
51	Cialis	Tadalafil	280,518	4.58%	Eli Lilly and Company, Lilly Icos	Erectile dysfunction	Nov-2002	Mon-20XX
52	Gilenya	fingolimod	272,701	4.05%	Novartis Corporation	Multiple sclerosis	Feb-2000	Jan-2007
53	Nasonex	Mometasone	272,345	5.67%	Schering-Plough	Allergic rhinitis	Oct-1997	Oct-2018
54	Stelara	Ustekinumab	270,598	12.47%	Johnson & Johnson	Psoriasis; psoriatic arthritis	Apr-2000	Mon-20XX
55	Restasis	Ciclosporin ophthalmic emulsion	268,463	6.30%	Allergan, Inc, Lilly Icos	Dry eye syndrome	Nov-2002	Mon-20XX
56	Budesonide	Budesonide	268,201	26.81%	Generic	Asthma	Aug-2000	Mon-20XX
57	Acetaminophen/hydrocodone	Acetaminophen/hydrocodone	264,814	6.67%	Generic	Pain	Aug-2000	Mon-20XX
58	Flovent HFA	Fluticasone propionate	263,072	13.97%	GlaxoSmithKline	Asthma	Mar-1996	Mon-20XX
59	Lovaza	Omega-3 fatty acid ethyl esters	258,177	2.90%	GlaxoSmithKline	Cholesterol	Jun-2001	Mon-20XX
60	Prezista	Darunavir	251,372	3.54%	Johnson & Johnson	HIV infection	Jun-2006	Mon-20XX
61	Isentress	Raltegravir	248,924	0.72%	Merck & Co., Inc.	HIV Infection	Dec-1998	Mon-20XX
62	Janumet	Sitagliptin/metformin	247,150	4.65%	Merck & Co., Inc.	Diabetes mellitus type 2	Dec-1998	Mon-20XX
63	Procrit, Eprex	Epoetin alfa	241,535	-10.09%	Johnson & Johnson	Anemia	Dec-1990	Mon-20XX
64	Doxycycline	Doxycycline	241,381	-5.65%	Generic	Bacterial infections	Dec-1996	Nov-2011
65	Orencia	Abatacept	241,149	1.65%	Bristol-Myers Squibb Company	Rheumatoid arthritis	Aug-2000	Mon-20XX
66	Amphetamine/dextroamphetamine	Amphetamine mixed salts	240,482	2.78%	Generic	Attention deficit hyperactivity disorder; narcolepsy	Feb-2004	Mon-20XX
67	Vesicare	Solifenacin	240,435	5.37%	Astellas Pharma US	Overactive bladder	Feb-2000	Nov-2018
68	Dexilant	Dexlansoprazole	238,897	7.57%	Takeda Pharmaceuticals North America, Inc	Gastrointestinal disorders	Dec-2004	Jul-2012
69	Humalog KwikPen	Insulin lispro	238,418	11.02%	Eli Lilly and Company	Diabetes mellitus type 1 and 2	Apr-1996	Mon-20XX
70	Neupogen	Filgrastim	229,912	-2.70%	Amgen	Neutropenia	Feb-1991	Mon-20XX
71	Lidocaine	Lidocaine	225,903	0.00%	Generic	Pain	Mar-1999	Mon-20XX
72	Lunesta	Eszopiclone	225,101	5.24%	Sunovion Pharmaceuticals Inc.	Insomnia	Dec-2004	Mon-20XX
73	Fenofibrate	Fenofibrate	223,300	-2.22%	Generic	Cholesterol	Feb-1998	Mon-20XX
74	Zytiga	Modafinil	222,026	11.86%	Centocor Ortho Biotech, Inc.	Shift work sleep disorder; narcolepsy	Dec-1998	Mon-20XX
75	Reyataz	Atazanavir	217,793	-1.38%	Bristol-Myers Squibb	HIV infection	Jan-2003	Mon-20XX
76	Sensipar	Cinacalcet	216,657	13.71%	Amgen Inc.	Hyperparathyroidism	Apr-2000	Mon-20XX
77	Metoprolol	Metoprolol	215,111	2.99%	Generic	Hypertension	Jan-1992	Mon-20XX
78	Invega Sustenna	Rabeprazole	214,251	10.03%	Janssen Pharmaceuticals, Inc, Johnson & Johnson	Gastrointestinal disorders	Aug-1999	Nov-2013
79	Synthroid	Levothyroxine	213,424	-2.50%	Abbott Laboratories	Hypothyroidism	May-1999	Mon-20XX
80	Avonex Pen	Olmesartan	211,917	13.59%	Biogen Idec,Forest Laboratories	Hypertension	Apr-2002	Apr-2016
81	Prevnar 13	Pneumococcal conjugate vaccine	209,367	6.41%	Wyeth	Pneumococcal disease	Feb-2000	Jan-2007
82	Xolair	Omalizumab	207,891	1.91%	Genentech,Novartis	Asthma	2003	Mon-20XX
83	Combivent Respimat	Atorvastatin	207,542	4.23%	Generic	Cholesterol	Dec-1996	Nov-2011
84	levothyroxine	Levothyroxine	204,755	0.00%	Generic	Hypothyroidism	Aug-1990	Mon-20XX
85	Benicar	Olmesartan/hydrochlorothiazide	203,336	3.22%	Daiichi Sankyo	Hypertension	Jun-1909	Mon-2016
86	Stribild	Linezolid	202,642	0.00%	Pfizer	Bacterial infections	Apr-2000	Mon-20XX
87	Zostavax	Zostavax	202,240	15.17%	Eisai, Merck & Co.	Herpes zoster	Aug-1999	May-2013
88	Pradaxa	Dabigatran	200,697	-0.53%	Boehringer Ingelheim, Lilly Icos	Oral anticoagulant	Oct-2010	Mon-20XX
89	Vytorin	Ezetimibe/simvastatin	199,625	-3.02%	Merck & Co.,Schering-Plough	Cholesterol	Jul-2004	Mon-20XX
90	Tamiflu	Oseltamivir	197,718	0.00%	Chugai Pharmaceutical,Hetero Drugs,Roche	Influenza	Oct-1999	Mon-20XX
91	Xgeva	Denosumab	197,711	3.24%	Amgen	Osteoporosis	Nov-2010	Mon-20XX
92	Evista	Raloxifene	196,929	-4.31%	Eli Lilly and Company, Chugai Pharmaceutical	Osteoporosis	Dec-1997	Jan-2013
93	Xeloda	Capecitabine	194,044	6.52%	Chugai Pharmaceutical,Genentech	Cancer	Jun-1909	Mon-20XX
94	Aranesp	Darbepoetin alfa	185,225	−9.22%	Amgen Inc.	Anemia	Jun-2001	Mon-20XX
95	Ventolin HFA	Salbutamol	183,060	0.00%	GlaxoSmithKline	Asthma; chronic obstructive pulmonary disease	May-1981	Mon-20XX
96	divalproex sodium	Depakote	181,554	0.00%	Generic	Gastrointestinal disorders	Jun-1909	Mon-20XX
97	Afinitor	Dexmethylphenidate	180,719	0.03%	Novartis	Attention deficit hyperactivity disorder	Jun-1909	Mon-20XX
98	Betaseron, Betaferon	Interferon beta 1b	179,216	-3.72%	Bayer	Multiple sclerosis	Jul-1993	Mon-20XX
99	Adderall XR	Amphetamine mixed salts	177,505	3.31%	Shire	Attention deficit hyperactivity disorder	Oct-2001	Mon-20XX
100	Complera	Emtricitabine/Rilpivirine/Tenofovir disoproxil fumarate	174,933	0.00%	Gilead Sciences, Inc.	AIDS	Jun-20XX	Mon-20XX